CBD has proven to be an effective natural remedy for anxiety doctor about the benefits, risks and process behind CBD oil for anxiety treatment. Cannabidiol is a compound derived from cannabis plants. It may help people with anxiety reduce their symptoms with few or no side effects. Likewise, evidence from human studies supports an anxiolytic role of CBD, but is to the potential risks and benefits of CBD as a treatment for anxiety disorders.
anxiety benefits oil cbd
CBD has broad therapeutic properties across a range of neuropsychiatric disorders, stemming from diverse central nervous system actions [ 11 , 12 ]. In recent years, CBD has attracted increasing interest as a potential anxiolytic treatment [ 13 — 15 ]. The purpose of this review is to assess evidence from current preclinical, clinical, and epidemiological studies pertaining to the potential risks and benefits of CBD as a treatment for anxiety disorders.
In total, 49 primary preclinical, clinical, or epidemiological studies were included. Neuroimaging studies that documented results from anxiety-related tasks, or resting neural activity, were included. THC ratio , were included. Cannabis sativa , a species of the Cannabis genus of flowering plants, is one of the most frequently used illicit recreational substances in Western culture.
The 2 major phyto- cannabinoid constituents with central nervous system activity are THC, responsible for the euphoric and mind-altering effects, and CBD, which lacks these psychoactive effects. Preclinical and clinical studies show CBD possesses a wide range of therapeutic properties, including antipsychotic, analgesic, neuroprotective, anticonvulsant, antiemetic, antioxidant, anti-inflammatory, antiarthritic, and antineoplastic properties see [ 11 , 12 , 16 — 19 ] for reviews.
Pharmacology relevant to these actions is detailed below. The primary mechanism by which eCBs regulate synaptic function is retrograde signaling, wherein eCBs produced by depolarization of the postsynaptic neuron activate presynaptic CB 1 Rs, leading to inhibition of neurotransmitter release [ 23 ]. Interactions with the TRPV1 receptor, in particular, appear to be critical in regulating the extent to which eCB release leads to inhibition or facilitation of presynaptic neurotransmitter release [ 25 ].
TRPV1 receptors are also expressed in the brain, including the amygdala, periaqueductal grey, hippocampus, and other areas [ 26 , 27 ]. The eCB system regulates diverse physiological functions, including caloric energy balance and immune function [ 28 ].
The eCB system is also integral to regulation of emotional behavior, being essential to forms of synaptic plasticity that determine learning and response to emotionally salient, particularly highly aversive events [ 29 , 30 ]. Activation of CB 1 Rs produces anxiolytic effects in various models of unconditioned fear, relevant to multiple anxiety disorder symptom domains reviewed in [ 30 — 33 ].
Regarding conditioned fear, the effect of CB 1 R activation is complex: CB 1 R activation may enhance or reduce fear expression, depending on brain locus and the eCB ligand [ 34 ]; however, CB 1 R activation potently enhances fear extinction [ 35 ], and can prevent fear reconsolidation. Genetic manipulations that impede CB 1 R activation are anxiogenic [ 35 ], and individuals with eCB system gene polymorphisms that reduce eCB tone—for example, FAAH gene polymorphisms—exhibit physiological, psychological, and neuroimaging features consistent with impaired fear regulation [ 36 ].
Reduction of AEA—CB 1 R signaling in the amygdala mediates the anxiogenic effects of corticotropin-releasing hormone [ 37 ], and CB 1 R activation is essential to negative feedback of the neuroendocrine stress response, and protects against the adverse effects of chronic stress [ 38 , 39 ]. Accordingly, CB 1 R activation has been suggested as a target for anxiolytic drug development [ 15 , 43 , 44 ].
In addition to dose-dependent activation of TRPV1 channels, the anxiogenic versus anxiolytic balance of CB 1 R agonists also depends on dynamic factors, including environmental stressors [ 33 , 49 ].
In preclinical studies, 5-HT 1A R agonists are anxiolytic in animal models of general anxiety [ 51 ], prevent the adverse effects of stress [ 52 ], and enhance fear extinction [ 53 ]. They are expressed on serotonergic neurons in the raphe, where they exert autoinhibitory function, and various other brain areas involved in fear and anxiety [ 54 , 55 ].
Mechanisms underlying the anxiolytic effects of 5-HT 1A R activation are complex, varying between both brain region, and pre- versus postsynaptic locus, and are not fully established [ 56 ].
Initial studies of CBD in these models showed conflicting results: When tested over a wide range of doses in further studies, the anxiolytic effects of CBD presented a bell-shaped dose—response curve, with anxiolytic effects observed at moderate but not higher doses [ 61 , 90 ].
All further studies of acute systemic CBD without prior stress showed anxiolytic effects or no effect [ 62 , 65 ], the latter study involving intracerebroventricular rather than the intraperitoneal route. No anxiogenic effects of acute systemic CBD dosing in models of general anxiety have yet been reported. As yet, few studies have examined chronic dosing effects of CBD in models of generalized anxiety. Anxiolytic effects in models used: Anxiolytic effects of CBD in models of generalized anxiety have been linked to specific receptor mechanisms and brain regions.
The midbrain dorsal periaqueductal gray DPAG is integral to anxiety, orchestrating autonomic and behavioral responses to threat [ 91 ], and DPAG stimulation in humans produces feelings of intense distress and dread [ 92 ]. The bed nucleus of the stria terminalis BNST serves as a principal output structure of the amygdaloid complex to coordinate sustained fear responses, relevant to anxiety [ 93 ].
In the prelimbic cortex, which drives expression of fear responses via connections with the amygdala [ 94 ], CBD had more complex effects: As noted, CBD has been found to have a bell-shaped response curve, with higher doses being ineffective. Stress is an important contributor to anxiety disorders, and traumatic stress exposure is essential to the development of PTSD. In a chronic study, systemic CBD prevented increased anxiety produced by chronic unpredictable stress, in addition to increasing hippocampal AEA; these anxiolytic effects depended upon CB 1 R activation and hippocampal neurogenesis, as demonstrated by genetic ablation techniques [ 81 ].
Finally, CBD, partially via CB 1 Rs, decreased defensive immobility and explosive escape caused by bicuculline-induced neuronal activation in the superior colliculus [ 89 ]. Several studies assessed CBD using contextual fear conditioning. Briefly, this paradigm involves pairing a neutral context, the conditioned stimulus CS , with an aversive unconditioned stimulus US , a mild foot shock.
After repeated pairings, the subject learns that the CS predicts the US, and subsequent CS presentation elicits freezing and other physiological responses. By contrast, CBD microinjection in the infralimbic cortex enhanced conditioned freezing [ 70 ]. Finally, El Batsh et al. In this study, CBD was administered prior to conditioning rather than prior to re-exposure as in acute studies, thus further directly comparable studies are required.
CBD has also been shown to enhance extinction of contextually conditioned fear responses. Extinction training involves repeated CS exposure in the absence of the US, leading to the formation of a new memory that inhibits fear responses and a decline in freezing over subsequent training sessions. Further studies showed CB 1 Rs in the infralimbic cortex may be involved in this effect [ 82 ].
CBD also blocked reconsolidation of aversive memories in rat [ 76 ]. Briefly, fear memories, when reactivated by re-exposure retrieval , enter into a labile state in which the memory trace may either be reconsolidated or extinguished [ 97 ], and this process may be pharmacologically modulated to achieve reconsolidation blockade or extinction.
Overall, existing preclinical evidence strongly supports the potential of CBD as a treatment for anxiety disorders. Activation of 5-HT 1A Rs appears to mediate anxiolytic and panicolytic effects, in addition to reducing conditioned fear expression, although CB 1 R activation may play a limited role. While CBD predominantly has acute anxiolytic effects, some species discrepancies are apparent.
In addition, effects may be contingent on prior stress and vary according to brain region. Further receptor-specific studies may elucidate the receptor specific basis of this distinct dose response profile. Further studies are also required to establish the efficacy of CBD when administered in chronic dosing, as relatively few relevant studies exist, with mixed results, including both anxiolytic and anxiogenic outcomes. In particular, results show potential for the treatment of multiple PTSD symptom domains, including reducing arousal and avoidance, preventing the long-term adverse effects of stress, as well as enhancing the extinction and blocking the reconsolidation of persistent fear memories.
The anxiolytic effects of CBD in humans were first demonstrated in the context of reversing the anxiogenic effects of THC.
CBD reduced THC-induced anxiety when administered simultaneously with this agent, but had no effect on baseline anxiety when administered alone [ 99 , ]. Further studies using higher doses supported a lack of anxiolytic effects at baseline [ , ]. By contrast, CBD potently reduces experimentally induced anxiety or fear. CBD reduced anxiety associated with a simulated public speaking test in healthy subjects, and in subjects with SAD, showing a comparable efficacy to ipsapirone a 5-HT 1A R agonist or diazepam [ 98 , ].
CBD also reduced the presumed anticipatory anxiety associated with undergoing a single-photon emission computed tomography SPECT imaging procedure, in both healthy and SAD subjects [ , ]. Finally, CBD enhanced extinction of fear memories in healthy volunteers: These rCBF changes were not correlated with anxiolytic effects [ ]. In a series of placebo-controlled studies involving 15 healthy volunteers, Fusar-Poli et al. Response activation is diminished in PTSD and other anxiety disorders, and increased activation predicts response to treatment [ ].
CBD produced no changes in predicted areas relative to placebo but reduced activation in the left insula, superior temporal gyrus, and transverse temporal gyrus.
The fearful faces task activates the amygdala, and other medial temporal areas involved in emotion processing, and heightened amygdala response activation has been reported in anxiety disorders, including GAD and PTSD [ , ]. CBD attenuated blood-oxygen-level dependent activation in the left amygdala, and the anterior and posterior cingulate cortex in response to intensely fearful faces, and also reduced amplitude in skin conductance fluctuation, which was highly correlated with amygdala activation [ ].
Dynamic causal modeling analysis in this data set further showed CBD reduced forward functional connectivity between the amygdala and anterior cingulate cortex [ ]. Epidemiological studies of various neuropsychiatric disorders indicate that a higher CBD content in chronically consumed cannabis may protect against adverse effects of THC, including psychotic symptoms, drug cravings, memory loss, and hippocampal gray matter loss [ — ] reviewed in [ ].
As THC acutely induces anxiety, this pattern may also be evident for chronic anxiety symptoms. Two studies were identified, including an uncontrolled retrospective study in civilian patients with PTSD patients [ ], and a case study in a patient with severe sexual abuse-related PTSD [ ], which showed that chronic cannabis use significantly reduces PTSD symptoms; however, these studies did not include data on the THC: Thus, overall, no outcome data are currently available regarding the chronic effects of CBD in the treatment of anxiety symptoms, nor do any data exist regarding the potential protective effects of CBD on anxiety potentially induced by chronic THC use.
Evidence from human studies strongly supports the potential for CBD as a treatment for anxiety disorders: Limited results in healthy subjects also support the efficacy of CBD in acutely enhancing fear extinction, suggesting potential for the treatment of PTSD, or for enhancing cognitive behavioral therapy.
Further studies are also required to establish whether chronic, in addition to acute CBD dosing is anxiolytic in human. Human experimental findings support preclinical findings, and also suggest a lack of anxiogenic effects, minimal sedative effects, and an excellent safety profile.
Overall, this review emphasizes the potential value and need for further study of CBD in the treatment of anxiety disorders. Disclosure forms provided by the authors are available with the online version of this article.
National Center for Biotechnology Information , U. They also gave me a cannabinol patch to use at night fir the severe itch in my head from the shingles.
Also a vape two puffs as needed for the itch break through which I have not tried yet. I have been totally off the effexor and all anti-depressants for 2 weeks now. I realize most of this has to do with the withdrawal. I really want to see this through to find out if I can live without anti-depressants but at the same time I know it's very hard on my family.
I have another doctor appt beginning of April and she says that if I don't feel better by then I most likely will need to go back on an anti-depressant. For the most part I agree with her.
My hopes of proving her wrong as getting slim however. I'd like to know how long it took some of you who have withdrawn from anti-depressants to feel somewhat 'normal' or you knew you had to go back on them? I guess I'm asking if another month is a good amount of time for me to determine what I should do. In some ways I feel like I should start on them again now but I'm not going there yet? BTW, I am in no way feeling suicidal.
Mornings seem to be my worst time and by early evenings I feel somewhat better — is this strange too? I haven't tried the CBD living water yet but did find a place near me to get it. Just havent had the time to get there. I also have the Ativan which I take one night to help with sleep.
I'm trying not to take it unless really necessary. Tomorrow I have a huge even that my husband and I are in charge of so I'm planning to take an Ativan in the morning to get me through the day without falling apart crying scene in front of everyone or yelling at them: Thanks for all your input!!
Liked by Gail, Volunteer Mentor , danalee5. The meds were wrong for me and the withdrawal was severe and I rarely slept, had RLS, neuropathy and cranky beyond words.
Be sure to follow doctor's advice. I did not have a doctor at the time and would not go to the ER knowing it would have resulted in more abuse. Not an intelligent thing to do and not sorry I made the choice even though the experience was horrific and would not reccomend anyone go this route.
As to how long the withdrawal lasts the best thing is to discuss this with a pharmacist as this is where their training is and they understand much better and be of help. Wishing you the best. Liked by Gail, Volunteer Mentor , kygirl25 , lalyfa. Hopefully not more than a week or two off the Effexor but I don't know what else you're getting off. Best to you, may you feel well soon. Glad you're off that stuff and sorry to hear about the hell of cold turkey on that stuff.
I've had a taste of that horror missing doses of a benzo, clonazepam, and now tapering slowly over 5 months. The other things — weed psychological addiction, sugar, caffeine, gonna white knuckle the weed as I'm out soon and saving to take the bar exam.
I'm going to try using CBD oil as I heard it's effective at reducing anxiety, lifting mood, and so on. Thank you for sharing and wishing you, too, and us all, good health and peace. Will ask my pharmacist about expected withdrawal. Liked by Gail, Volunteer Mentor , Parus. I never thought to check with my pharmacist but it sounds like a wise suggestion! Been on CBD oil for 7 days seems to help some but I have break through depression like today which is causing crying and nausea, have my self wrapped up in blankets fighting all this crap which has been caused from coming off Lyrica.
Training Community Outreach Online Outreach. Oldest to Newest Newest to Oldest. Gail, Volunteer Mentor gailb Posts: Gary, Volunteer Mentor gman Posts: They come from hemp strains that have varying amounts of terpenes…some beneficial to anxiety, others not as much. Depending on how the oil was processed and what phytochemical profile it had to begin with, will impact its affect on you.
I have been using Purekana for 13 months to help with my chronic anxiety. Before discovering this brand I had smoked cannabis but found it made my symptoms much worse and I had several panic attacks. I have also been using this brand for a while. I prefer their capsules over the oils. A tincture under your tongue is the best method. I feel so relaxed lately. I was willing to try whatever to get a hold of my anxiety. CBD has helped so much and has given me an overall sense of calm.
Not to mention I am sleeping better. I have been using a CBD mg for the last 2 months. I have just started. Honestly I thought it was all hocus pocus. So honestly at first I thought this was all hocus pocus, but I must say that I am surprised by the results. Excellent if you are looking for an alternative way to treat your condition.
Wow, really helpful FAQ video there above the comments section. Must agree with Hank. Based on this article I ordered purekana. Will keep you all posted. Hope it stays this way. Just got my order today. I deal with dizziness and anxiety on a daily basis. I was a bit scared since this is new to me and get nervous when trying something new. So, I bought mg and put 2 drops under tongue. I herniated a disc first, then months later the disc popped chipping my vertebrae, spinal fusion C, in Realizing then the pain was actually a nerve in my neck but it was too late, the damage to my hip socket had already been done.
Susanne, Which brand and concentration of CBD did you use? Might want to target your search that way. You have to try CBD to see how it works for you. How do you know what dosages to try? And how long before you move to a stronger dosage? I know that most say that you should start on a low dosage and work your way up, but i got the higher mg one and just cut it down and worked up from there.
Works great for me. My husband bought me Skywalker Indica for my anxiety and the reviews seem to show that it has a really high potency. I am a beginner and do not want to take anti depressants. Can anyone enlighten me as to whether or not this strain of oil would be too much for a newbie? Leave a Reply Cancel reply. Your email address will not be published. Remember me Lost your password?
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7 Best CBD Oils For Anxiety [ 2019 Update ]
For people with anxiety, CBD oil is touted as an all-natural way to find relief. Find out whether this marijuana compound can help ease your. Nevertheless, it has enormous health advantages, including treating anxiety. Particular studies on CBD oil anxiety, have soar exponentially. Here are seven health benefits of CBD oil that are backed by scientific CBD oil has even been used to safely treat insomnia and anxiety in.