Effects of cannabinoids on testosterone and protein synthesis in rat testis Leydig than CBN = CBD = CBG greater than or equal delta 9-THC = delta 8-THC. CBD and testosterone are two intricately tied yet poorly understood topics when the impact CBD oil may have on your testosterone levels. For smaller dosages, THC tends to increase testosterone production quite dramatically. However, mice that were given larger doses showed a marked decline in.
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Can hemp oil with CBD treat Lyme disease, fibromyalgia, and other chronic illness? Cannabis sativa was one of the earliest plants cultivated by humankind. The very first use of cannabis was documented in China around BC. A very versatile plant, it was used for food, medicine, religious and spiritual rituals, industrial fiber, and, of course, recreation. From China, cannabis spread to India, the Arabian Peninsula, and then on to Europe with the spice trade.
Through European colonization, use of cannabis spread to the Americas, Caribbean, and throughout the world. How the plant was used depended on the variety of cannabis, the parts of the plant, and how the plant was cultivated. The variety of cannabis known as hemp was traditionally valued primarily for its fibers with high tensile strength, making it ideal for creating rope and textiles. Hemp seeds and sprouts were eaten as a good source of high-quality protein and beneficial omega-3 fatty acids.
The variety of cannabis known as marijuana was specifically cultivated for the euphoric properties of THC, which is concentrated mostly in the flower buds of the plant. Only recently have the unique medicinal properties of both hemp and marijuana been fully recognized. Cannabis sativa has several alter egos, but marijuana and hemp are the two best known. Though both plants look the same, their chemical composition is quite different. The chemical difference has to do with the presence or absence of certain enzymes.
Both marijuana and hemp contain a chemical substance called cannabigerol CBGA , which is concentrated mostly in the flower buds of the plant. Remember, though, that there are many varieties of marijuana and hemp plants, and their concentrations of THC and CBD vary. Only cannabis with less than 0. There are different receptors for cannabinoid compounds located throughout the body. For instance, CB1 receptors are found in high concentrations in the brain and nervous system. CB2 receptors are located throughout the body, but predominantly within the lower body and immune system.
It weakly binds to both CB1 and CB2 receptors in the brain and body, gently stimulating and blocking them at the same time. This not only mildly activates the receptors, but is also thought to trigger the body to create more CB 1 and CB 2 receptors, a process known as upregulation. It also results in increased natural levels of anandamide. When the body experiences an increase in CB receptors, it becomes more sensitive to the natural endocannabinoids anandamide and others already present in the body.
CBD also modulates other receptors in the body. For instance, modulation of the 5-HT1A receptor involved with serotonin, a mood hormone provides mood-balancing properties: Another example is modulation of opioid receptors, which provides pain relief and tissue-supporting properties.
Cannabis plants also possess a wide spectrum of different chemical components offering a range of medicinal properties. Aside from cannabinoids, one of the most prominent chemicals in cannabis plants is terpenes, organic and aromatic compounds found in essential oils. Terpenes are beneficial on their own. For instance, research in the British Journal of Pharmacology found that terpenes are gastro-protective, suggesting they may be beneficial to people with ulcers, and that they have anti-inflammatory properties.
It also points to the importance of using a full-spectrum extract of hemp, which provides a full range of chemical components including terpenes, as opposed to purified CBD or CBD isolate, which contains only CBD.
Cannabinoids, including cannabidiol CBD , work by mimicking natural endocannabinoids like anandamide described above in the body. Endocannabinoids are part of a complex messaging system in the body called the endocannabinoid system. The endocannabinoid system oversees or regulates parts of the nervous system, endorphins, immune system functions, hormones, mood and emotions, metabolism, and many other chemical messengers in the body.
Like other cannabinoids, CBD readily crosses the blood brain barrier, making it ideal for affecting central nervous system conditions. CBD helps calm the nervous system, reduces inflammation, and is strongly neuroprotective. Not surprisingly, clinical studies evaluating cannabidiol for treatment of anxiety , post traumatic stress disorder PTSD , seizure disorders especially childhood seizures , and even schizophrenia have shown remarkable effectiveness.
Management of chronic pain is another application for which CBD is ideally suited, and it works in a number of ways. It and other non-THC cannabinoids found in hemp flower-bud extracts work to block pain-conducting nerve impulses, which reduces your perception of pain. Stimulation of CB 1 in the brain increases dopamine , which counteracts pain.
Just as importantly, these same chemical substances reduce inflammation , the driving force behind pain , which allows healing to occur. CBD and other cannabinoids also reduce pain by affecting endorphins, the feel-good chemicals we naturally produce to suppress pain. Unlike opioids heroin, narcotics , which mimic endorphins and ultimately suppress natural endorphins, cannabinoids modulate endorphins.
This means, in effect, that CBD and cannabinoids increase natural endorphins. So instead of causing dependence and addiction like opioids, CBD and cannabinoids do the opposite — so much so that CBD has proven valuable for countering narcotic and cocaine addiction. From a medicinal standpoint, the fact that CBD has the potential to relieve pain without causing euphoria, intoxication, or addiction makes it an intriguing therapeutic option — it has high potential for being at least a partial solution to the current opioid epidemic.
CBD and other chemical substances in hemp flower-bud extracts are strong immune system modulators. This means they control inflammation throughout the body, and also fine-tune the immune system for optimal performance. The wide range of benefits associated with cannabis have garnered interest for use in cancer therapy.
Research suggests that cannabinoids, including CBD, may have anti-tumor effects. While this is not enough to define cannabis as a treatment for cancer, it does make it attractive as a complement to other therapies , for both reducing symptoms and possibly enhancing the effects of anticancer drugs. Terpenes and the wide spectrum of other chemical compounds found in hemp flower-bud extracts provide potent anti-inflammatory and antioxidant properties.
This is a common source of confusion. Many people see hemp oil on grocery store shelves and assume or wonder if it contains CBD and other cannabinoids.
The hemp oil you might see on grocery store shelves is made by cold pressing hemp seeds. While hemp oil is a healthful option for a salad dressing, it has no medicinal value by itself. Cannabinoids, including CBD in hemp and THC in marijuana, are most highly concentrated in the flower buds, not the seeds. These chemical components of the plant must be extracted from the flower buds to be useful.
For medicinal use, cannabinoids are extracted from hemp and concentrated into a thick oil that, when ingested, elevates blood levels of cannabinoids for a more sustained period of time. CBD oil from hemp contains CBD and other cannabinoids, along with terpenes and other chemical components. The most common method, chemical extraction uses alcohol or hexane as solvents. The solvent is dried off, leaving the dense oil — and possibly harmful residual solvents — behind.
A newer method, CO 2 extraction is done without using chemical solvents. Instead, it uses carbon dioxide to extract the full range of chemical components from the flower buds and then distill them into dense CBD oil. Also sometimes called thermal extraction, vapor distillation uses hot air to safely vaporize the full spectrum of chemical components at high concentration from the buds, and then the vapor is distilled into CBD oil.
This method also activates the cannabinoids by removing an extra carboxyl ring from their molecular chain a chemical reaction called decarboxylation , enabling them to interact directly with CB receptors for maximal medicinal value. I believe vapor distillation is the best method for obtaining the full range of activated chemical compounds from the cannabis plant. This method preserves the terpenes, which are beneficial on their own, and also enhance the properties of CBD via the entourage effect.
The upsides of lipid-based extraction are that the fat helps make the CBD more bioavailable easy to absorb , and there are no harsh solvents used. Condensed CBD oil can be taken as a thick paste, but this is the least pleasant option. More commonly, the CBD oil is mixed with a carrier oil, such as hemp oil or coconut oil, to a specific concentration of CBD. The distinctive taste — which comes from the terpenes and not the cannabinoids — is often masked with chocolate, mint, or other flavorings.
It typically comes in a small bottle with a dropper to administer the oil mixture. The best way to take CBD oil mixed with a carrier oil to a specific concentration is to place a few drops or dropperfuls under your tongue for 15 seconds to access the sublingual gland.
There, the CBD is absorbed directly into the bloodstream called sublingual consumption or administration for the fastest acting effects. Another method is to take a few drops or dropperfuls orally, swish the liquid around in your mouth, and then swallow it. CBD oil mixed with a carrier oil can also be taken as soft-gel capsules to avoid any taste, but absorption is only through the intestinal tract. The average dose range is mg of CBD, one to three times per day, though much higher doses of mg sometimes required to control pain are equally well tolerated.
Some people will notice benefit at the lower end of the dose range, but most people will need mg to notice any effects. Because different products provide different concentrations of CBD, the packaging usually states how much CBD is in the entire bottle as opposed to the amount in a certain number of drops or dropperfuls, so measuring can be a little tricky.
A dropperful of the medium grade product mg of CBD per fluid ounce will deliver about 15 mg of CBD — a good starting dose. And a dropperful of a high concentration product mg CBD per fluid ounce will provide about 50 mg of CBD per dropperful. CBD oil is also available as soft gel capsules. With these, the mg quantity of CBD should be designated per capsule. Because some of the chemical compounds in capsules are lost during digestion, you may find you need to take a little more to experience the benefits.
As with any medicinal herb, start at a low dose and gradually build up to a higher dose as you get used to the effects of the substance. Most people notice benefits almost immediately, but some experts suggest that full benefit does not occur until after a couple of weeks of consecutive use. CBD isolate which is CBD alone acts very differently in the body than a spectrum of hemp chemical components. Here are some quick definitions:. The cannabis plant naturally generates cannabinoids, terpenes, and other chemical compounds to serve different functions in the plant.
These functions include regulatory properties, potent antioxidants, and protection from microbes and insects. Any creature that consumes the chemicals from the plant gains these same benefits. When you consume CBD oil, you gain the benefits of all those chemical substances in natural synergy. For that reason, you get full benefit at a dose range of mg.
CBD isolate is limited to that single chemical messenger. The synergy provided by the full spectrum of chemicals in CBD oil is lost. This is likely why clinical studies using purified CBD require very high doses, in the range of mg of CBD several times daily, to see a benefit. When CBD is formally legalized at the national level, prescription drugs providing high doses of purified CBD will become available several are already in the pipeline.
Reported side effects of hemp oil with CBD are generally mild and uncommon and can include tiredness, loose stools, and mild changes in appetite and weight either increased or decreased. Both hemp oil with CBD hemp flower-bud extracts and purified CBD CBD isolate have been shown in both animal and human clinical trials to be remarkably safe and well tolerated.
Prolonged use is not associated with an increased risk of side effects. In research studies , up to mg of purified CBD per day has been used to address various medical illnesses without reported harmful effects including changes in heart rate, blood pressure, temperature, oxygen and carbon dioxide levels, electrolyte balance, gastrointestinal function, psychomotor functions, or sleep cycles.
Excited to take your performance to new highs? Yes, pun very intended. Weed, as we know it, is cannabis cultivated for high levels of its psychoactive constituent, known as tetrahydrocannabinol THC.
Arguably, without the presence of this compound, the bioactive effects of weed changes altogether, from what we know it to be, to something that holds great promise to athletes. This is what CBD is. Possessing cannabis with high THC content is the topic for another discussion altogether, but just know it is illegal in many places. However, CBD is not like his better known cousin.
In fact, CBD was found in a study to interfere with the secretion of cortisol , reducing blood levels significantly.
Though the study that found these results included only 11 subjects, even without the scientific verification, anecdotal evidence has revealed that people who use THC rich cannabis strains are known to supplement with CBD to reduce the effects of anxiety and increased adrenal function that occurs. Are you hoping to build the body of a god on four hours sleep per night? CBD oil can help. It has a rather contradictory mechanism, as it is not a potent sedative, and should really even be classified as a stimulant.
CBD in very low doses activated the same adenosine receptors as caffeine, blocking the action of its substrate and preventing sleep.
However, at moderate to high doses which is the dose normally consumed for therapeutic benefit , it holds good potential as a sleep promoting agent. CBD once again has shown itself to have the opposite effect of THC, suppressing appetite and lending itself for use as an anti-obesity agent. Inflammation is ongoing every minute of the day.
In a way, inflammation is what is responsible for shortening of our lifespan , being responsible to a large degree for many of the chronic diseases that are the most common causes of mortality. Which begs the question: But life-extending benefits aside, we are more interested in keeping our bodies working at peak efficiency, since our goal is to enhance athletic performance. So how does CBD help us along the yellow brick road? For one, CBD can help relieve the inflammation that occurs in joints as a result of heavy weights or constant use wear and tear injuries.
You can have your diet on point, along with a top quality workout program, but yet it looks like your body refuses to part ways with your surplus of fat, nor is it willing to build muscle very fast. If this describes you, low insulin sensitivity is probably at fault. Optimally, your insulin should be low the majority of the time. Because insulin becomes more efficient the less it is recruited.
The Science Behind CBD Oil: Everything You Need to Know
Smoking weed regularly can impact your testosterone levels. And cannabis could wind up damaging your muscle gains and overall health too. On the one hand, CBD can help provide pain relief and lift your spirits. a slight dip in testosterone levels after a bit of time passes. of time after smoking, and then produces an opposite effect. New research is shedding light on how it can also impact men's testosterone levels. We're going to look at what the research says and talk.